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The film is considered 'culturally, historically or aesthetically' significant by the U.S. The American Film Institute ranked it the fifth-greatest and most influential thriller film while Starling and Lecter were ranked among the greatest film heroines and villains. In 2018, Empire ranked it 48th on their list of the 500 greatest movies of all time. The Silence of the Lambs is regularly cited by critics, film directors and audiences as one of the greatest and most influential films. It is also the only Best Picture winner widely considered a horror film, and one of only six horror films to have been nominated in the category with The Exorcist (1973), Jaws (1975), The Sixth Sense (1999), Black Swan (2010), and Get Out (2017). It became the third and most recent film (the other two being 1934's It Happened One Night and 1975's One Flew Over the Cuckoo's Nest) to win Academy Awards in all the major five categories: Best Picture, Best Director, Best Actor, Best Actress, and Best Adapted Screenplay.

It premiered at the 41st Berlin International Film Festival, where it competed for the Golden Bear, while Demme received the Silver Bear for Best Director. The Silence of the Lambs was released on February 14, 1991, and grossed $272.7 million worldwide on a $19 million budget, becoming the fifth-highest-grossing film of 1991 worldwide.

The film also features performances from Scott Glenn, Anthony Heald and Kasi Lemmons. Hannibal Lecter ( Anthony Hopkins), a brilliant psychiatrist and cannibalistic serial killer. To catch him, she seeks the advice of the imprisoned Dr. It stars Jodie Foster as Clarice Starling, a young FBI trainee who is hunting a serial killer, ' Buffalo Bill' ( Ted Levine), who skins his female victims. The Silence of the Lambs is a 1991 American psychological horror film directed by Jonathan Demme and written by Ted Tally, adapted from Thomas Harris's 1988 novel.

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